Precautions after a dilated eye exam: the possibility and risk of an acute glaucoma attack

In a small number of people with “high-risk eyes” (a narrow anterior chamber angle or strong hyperopia), an acute glaucoma attack can occur, very rarely, after a dilated (mydriatic) eye exam.
However, there is no problem if an ophthalmologist treats it promptly.

The symptoms of an acute glaucoma attack are

  • headache
  • vomiting
  • eye pain
急性閉塞隅角緑内障の症状の図解(日英併記):中央に隅角が閉塞した眼球断面図を置き、眼圧上昇・頭痛・充血・吐き気/嘔吐・光を見ると虹のような輪が見える・目および眉毛の痛み・角膜浮腫・視界がぼやける(かすむ)の8つの症状を矢印で示す


An acute glaucoma attack is caused by blockage of the anterior chamber angle, the drainage pathway for the fluid inside the eye (angle closure).
Angle closure raises eye pressure sharply and damages the nerve tissue at the back of the eye: the retina and the optic nerve.

正常な眼と緑内障の眼を比較した断面イラスト(英語表記):正常では房水の排出路(drainage channel)が通っているのに対し、緑内障では排出路がふさがれて眼圧が上昇(pressure buildup)し、視神経に変化が生じることを示す
Acute glaucoma attack

In an acute glaucoma attack,
in particular,severe headache and vomitingoften appear, so the first thought is to see an internist or a neurosurgeon rather than an eye doctor.
While tests are being done at the internal medicine or neurosurgery clinic, the eye pressure stays high.

What is frightening is that
while the cause of the headache and vomiting is being investigated, damage to the retina and optic nerve keeps advancing.
It can leave irreversible visual impairment.

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Precautions after a dilated eye exam: the possibility and risk of an acute glaucoma attack

Eyes at high risk of an acute glaucoma attack

Before dilation, it is already possible to tell who is at high risk of an acute glaucoma attack.
They are people who are farsighted (hyperopic) and have a narrow anterior chamber angle (narrow angle).

Hyperopia, emmetropia and myopia
近視と遠視の眼球断面図の比較:近視は眼軸が長くピントが網膜の手前に結ぶためマイナスレンズで矯正、遠視は眼軸が短いためプラスレンズで矯正することを示す

A hyperopic eye has a short axial length, so the anterior chamber angle is relatively narrow: a “narrow-angle” state.

Classification of narrow angle

Dilation is usually done with Mydrin®-P and Neosynesin® eye drops.
If the examination before dilation shows a narrow angle, the pupil is dilated with Neosynesin® eye drops.
This is a way to reduce, as far as possible, the risk of causing an acute glaucoma attack.

Even so, a glaucoma attack may occur on the way home or after getting home.

How to tell whether you are having an acute glaucoma attack

Acute glaucoma attack after a dilated exam: eyes prone to it, three signs to check, and who to contact right away
Figure: Signs of an acute glaucoma attack after a dilated exam, and what to do

“Is what I am experiencing now an acute glaucoma attack?”

Cover one eye and check whether each eye
sees as clearly as usual.

  • In a hyperopic eye,
  • with severe headache and vomiting,
  • if one eye cannot see or the vision is blurred,

it may be a headache and vomiting caused by an acute glaucoma attack.

If it is outside clinic hours,
the emergency department of a university hospital
an emergency clinic, or similar

and contact them.

“I may be having an acute glaucoma attack after a dilated eye exam.”
“I am hyperopic and was told my eyes are at risk of an acute glaucoma attack.”

Please tell them both of these things.

Treatment of an acute glaucoma attack

(1) Lower the eye pressure with an intravenous drip
(2) Once the eye pressure has settled, perform surgery to remove the crystalline lens
(cataract surgery to prevent recurrence of an acute glaucoma attack)

Narrow-angle eyes and after an acute glaucoma attack: cataract surgery
Narrow-angle eyes and after an acute glaucoma attack: cataract surgery

In the past, laser surgery (laser iridotomy, LI) was the usual approach.
It places a heavy burden on the corneal endothelium, and decades later there is a risk of developing bullous keratopathy.

What is bullous keratopathy?
Water enters the corneal stroma and the cornea becomes swollen and waterlogged.
A corneal transplant may be needed.

角膜内皮細胞の定期検査の説明図:角膜の透明性を維持する再生しない細胞であること、スペキュラーマイクロスコープ画像で正常・極端な減少・大小不同(コンタクトレンズ装用者)の3例を比較
レーザー虹彩切開術の図解:隅角閉塞や瞳孔ブロックで房水が流れにくくなった眼の断面図に、YAG/アルゴンレーザーで虹彩に穴を開けて房水の逃げ道をつくり、急激な眼圧上昇を回避する流れを示す

Laser iridotomy for narrow-angle eyes is now a method that is no longer recommended.1

The risk of an acute glaucoma attack: how not to worry too much

Even with hyperopia, most people go through life without anything happening.
It is fine to forget about it in everyday life.
Even so, I would like you to be able to recall the condition of your own eyes.


We also give you a card to show if anything happens.

These days, it is also possible to examine the fundus without dilating the pupil.

References

  1. He, M., Jiang, Y., Huang, S., Chang, D.S., Munoz, B., Aung, T., Foster, P.J., Friedman, D.S., 2019. Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial. The Lancet 393, 1609–1618. https://doi.org/10.1016/S0140-6736(18)32607-2

Takeru Yoshimura, M.D., Ph.D.

たける眼科
takeru-eye.com
福岡市早良区「高取商店街」
西新駅/藤崎駅(福岡市地下鉄)

日本眼科学会 眼科専門医
医学博士(九州大学)

Takeru Yoshimura, M.D., Ph.D.

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